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研究論文
2022年
Saito A#, Irie T#, Suzuki Rigel#, Maemura T#, Nasser H#, Uriu K#, Kosugi Y# (#equal contribution), Shirakawa K, Sadamasu K, Kimura I, Ito J, Wu J, Iwatsuki-Horimoto K, Ito M, Yamayoshi S, Loeber S, Tsuda M, Wang L, Ozono S, Butlertanaka EP, Tanaka Y, Shimizu R, Shimizu K, Yoshimatsu K, Kawabata R, Sakaguchi T, Tokunaga K, Yoshida I, Asakura H, Nagashima M, Kazuma Y, Nomura R, Horisawa Y, Yoshimura K, Takaori-Kondo A, Imai M, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Tanaka S*, Nakagawa S*, Ikeda T*, Fukuhara T*, Kawaoka Y*, Sato K* (*equal correspondence). Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation. Nature. 603, 700-705, 2022. [論文]
Nasser H, Fukuda T, Ikeda T, Saitoh H. Basic structure and cytocompatibility of giant membrane vesicles derived from paraformaldehyde-exposed human cells. J Biochem. 171, 339-347, 2022. Okada S, Fukai Y, Tanoue Y,
Suzuki R, Yamasoba D, Kimura I, Wang L, Kishimoto M, Ito J, Morioka Y, Nao N, Nasser H, Uriu K, Kosugi Y, Tsuda M, Orba Y, Sasaki M, Shimizu R, Kawabata R, Yoshimatsu K, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Sawa H, Ikeda T, Irie T, Matsuno K, Tanaka S, Fukuhara T, Sato K. Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant. Nature. 603, 700-705, 2022. [論文].
Meng B, Abdullahi A, Ferreira IATM, Goonawardane N, Saito A, Kimura I, Yamasoba D, Gerber PP, Fatihi S, Rathore S, Zepeda SK, Papa G, Kemp SA, Ikeda T, Toyoda M, Seng TT, Kuramochi J, Mitsunaga S, Ueno T, Shirakawa K, Takaori-Kondo A, Brevini T, Mallery DL, Charles OJ, CITIID-NIHR BioResource COVID-19 Collaboration, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Bowen JE, Joshi A, Walls AC, Jackson L, Martin D, Smith KGC, Bradley J, Briggs JAG, Choi J, Madissoon E, Meyer K, Mlcochova P, Ceron-Gutierrez L, Doffinger R, Teichmann SA, Fisher AJ, Pizzuto MS, de Marco A, Corti D, Hosmillo M, Lee JH, James LC, Thukral L, Veesler D, Sigal A, Sampaziotis F, Goodfellow IG, Matheson NJ, Sato K, Gupta RK. Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity. Nature. 603, 706-714, 2022. [論文].
Rajib SA, Ogi Y, Hossain MB, Ikeda T, Tanaka E, Kawaguchi, Satou Y. A SARS-CoV-2 Delta variant containing mutation in the probe binding region used for RT-qPCR test in Japan exhibited atypical PCR amplification and might induce false negative result. J Infect Chemother. 28, 669-667, 2022.
Yamasoba D#, Kimura I#, Nasser H#, Morioka Y#, Nao N#, Ito J#, Uriu K#, Tsuda M#, Zahradnik J# (#equal contribution), Shirakawa K, Suzuki R, Kishimoto M, Kosugi Y, Kobiyama K, Hara T, Toyoda M, Tanaka YL, Butlertanaka EP, Shimizu R, Ito H, Wang L, Oda Y, Orba Y, Sasaki M, Nagata K, Yoshimatsu K, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Kuramochi J, Seki M, Fujiki R, Kaneda A, Shimada T, Nakada T, Sakao S, Suzuki T, Ueno T, Takaori-Kondo A, Ishii KJ, Schreiber G, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Sawa H, Saito A*, Irie T*, Tanaka T*, Matsuno K*, Fukuhara T*, Ikeda T*, Sato K* (*equal correspondence). Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike. Cell. 185, 2103-2115.e19, 2022. [論文]
Kimura I#, Yamasoba D#, Tamura T#, Nao N#, Suzuki T#, Oda Y#, Mitoma S#, Ito J#, Nasser H#, Zahradnik J#, Uriu K, Fujita S, Kosugi Y, Wang L, Tsuda M, Kishimoto M, Ito H, Suzuki R, Shimizu R, Begum MM, Yoshimatsu K, Kimura KT, Sasaki J, Sasaki-Tabata K, Yamamoto Y, Nagamoto T, Kanamune J, Kobiyama K, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Shirakawa K, Takaori-Kondo A, Kuramochi J, Schreiber G, Ishii KJ, Hashiguchi T, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Hashiguchi T*, Ikeda T*, Saito A*, Fukuhara T*, Tanaka S*, Matsuno K*, Sato K* (*equal correspondence). Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants including BA.4 and BA.5. Cell. In press, 2022. [論文].
Nasser H, Shimizu R, Ito J, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Saito A, Sato K, Ikeda T*(*correspondence). Monitoring fusion kinetics of viral and target cell membranes in living cells using a SARS-CoV-2 spike protein-mediated membrane fusion assay. STAR Protoc. 3, 101773, 2022. [論文].
Saito A#, Tamura T#, Zahradnik J#, Deguchi S#, Tabata K#, Anraku Y#, Kimura I#, Ito J#, Yamasoba D# (#equal contribution), Nasser H, Toyoda M, Nagata K, Uriu K, Kosugi Y, Fujita S, Maya Shofa, Begum MM, Shimizu R, Oda Y, Suzuki R, Ito H, Nao N, Wang L, Tsuda M, Yoshimatsu K, Kuramochi J, Kita S, Sasaki-Tabata K, Fukuhara H, Maenaka K, Yamamoto Y, Nagamoto T, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Ueno T, Schreiber G, Takaori-Kondo A, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Shirakawa K, Sawa H, Irie T, Hashiguchi T, Takayama K, Matsuno K, Tanaka S*, Ikeda T*, Fukuhara T*, Sato K* (*equal correspondence). Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant. Cell Host Microbe. 30, 1540-1555.e15, 2022. [論文].
Kimura I#, Yamasoba D#, Nasser H#, Zahradnik J#, Kosugi Y#, Wu J# (#equal contribution), Nagata K, Uriu, K, Tanaka YL, Ito J, Shimizu R, Tan TS, Butlertanaka EP, Asakura H, Sadamasu K, Yoshimura K, Ueno T, Takaori-Kondo A, Schreiber G, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Toyoda M, Shirakawa K, Irie T, Saito A*, Nakagawa S*, Ikeda T*, Sato K* (*equal correspondence). The SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant. iScience. In press. 2022. [論文].
2021年
Abe T, Ikeda T, Tokuda Y, Ito J, Suzuki Y, Narahara C, Iriyama H Sato K. A patient infected with SARS-CoV-2 over 100 days. QJM: An International Journal of Medicine, 114, 47-49. 2021.
Motozono C, Toyoda M, Zahradnik J, Saito A, Nasser H, Tan TS, Ngare I, Kimura I, Uriu K, Kosugi Y, Yue Y, Shimizu R, Ito J, Torii S, Yonekawa A, Shimono N, Nagasaki Y, Minami R, Toya T, Sekiya N, Fukuhara T, Matsuura Y, Schreiber G, The Genotype to Phenotype Japan (G2P-Japan) consortium, Ikeda T*, Nakagawa S*, Ueno T*, Sato K* (*equal correspondence). SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity. Cell Host Microbe. 29, 1124-1136.e11, 2021. [論文]
Kaku Y, Kuwata T, Zahid HM, Hashiguchi T, Noda T, Kuramoto N, Biswas S, Matsumoto K, Shimizu M, Kawanami Y, Shimura K, Onishi C, Muramoto Y, Suzuki T, Sasaki J, Nagasaki Y, Minami R, Motozono C, Toyoda M, Takahashi H, Kishi H, Fujii K, Tatsuke T, Ikeda T, Maeda Y, Ueno T, Koyanagi Y, Iwagoe H, Matsushita S. Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-19. Cell Rep. 36, 109385, 2021.
Fukuda M, Islam MS, Shimizu R, Nassar H, Rabin NN, Takahashi Y, Sekine Y, Lindoy LF, Fukuda T*, Ikeda T*, Hayami S* (*equal correspondence). Lethal interactions of SARS-CoV-2 with graphene oxide: Implications for COVID-19 treatment. ACS Appl Nano Mater. 2021. 4, 11881-11887. [論文].
2020年
Nakano Y, Yamamoto K, Takahashi Ueda M, Soper A, Konno Y, Kimura I, Uriu K, Kumata R, Aso H, Misawa N, Nagaoka S, Shimizu S, Mitsumune K, Kosugi Y, Juarez-Fernandez G, Ito J, Nakagawa S, Ikeda T, Koyanagi Y, Harris RS and Sato K. A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans. PLoS Pathog, 16, e1008812. 2020.
2019年
Ikeda T*, Walker SN*, Tennyson RL*, Harris RS, and McNaughton BR (*equal contribution). Evolved Proteins Inhibit Entry of Enfuvirtide-Resistant HIV-1. ACS Infect Dis. 5, 634-640. 2019. [論文]
Ikeda T*, Molan AM*, Jarvis MC, Carpenter MA, Salamango DJ, Brown WL, and Harris RS (*equal contribution). HIV-1 restriction by endogenous APOBEC3G in the myeloid cell line THP-1. J Gen Virol. 100, 1140-1152. 2019. [論文]
Salamango DJ, Ikeda T, Moghadasi SA, Wang J, McCann JL, Serebrenik A, Ebrahimi D, Jarvis MC, Shaban NM, Brown WL, and Harris RS. HIV-1 Vif triggers cell cycle arrest by degrading cellular PPP2R5 phospho-regulators. Cell Rep. 29, 1057-1065.e4. 2019.
2018年
Ikeda T, Symeonides M, Albin JS, Li M, Thali M, and Harris RS. HIV-1 adaptation studies reveal a novel Env-mediated homeostasis mechanism for evading lethal hypermutation by APOBEC3G. PLoS Pathog. 14, e1007010. 2018. [論文]
Tennyson RL, Walker SN, Ikeda T, Harris RS, and McNaughton BR. Evaluation of sequence variability in HIV-1 gp41 C-peptide helix-grafted proteins. Bioorg Med Chem. 26, 1220-1224. 2018.
Ebrahimi D, Richards CM, Carpenter MA, Wang J, Ikeda T, Becker JT, Cheng, AZ, McCann JL, Shaban NM, Salamango DJ, Starrett GJ, Lingappa JR, Yong J, Brown WL, and Harris RS. Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease. Nat Commun. 9, 4137. 2018.
Anderson BD*, Ikeda T*, Moghadasi SA*, St. Martin A, Brown WL and Harris RS (*equal contribution). Natural APOBEC3C variants can elicit differential HIV-1 restriction activity. Retrovirology. 15, 78. 2018. [論文]
2017年
Ikeda T*, Shimoda M, Ebrahimi D, VandeBerg JL, Harris RS, Koito A, and Maeda K* (*equally correspondence). Opossum APOBEC1 is a DNA mutator with retrovirus and retroelement restriction activity. Sci Rep. 7, 46719. 2017. [論文]
2016年
Ikeda T*, Ong EB, Watanabe N, Sakaguchi N, Maeda K*, and Koito A (*equal correspondence). Creation of chimeric human/rabbit APOBEC1 with HIV-1 restriction and DNA mutation activities. Sci Rep. 6, 19035. 2016. [論文]
Yoshikawa R, Izumi T, Yamada E, Nakano Y, Misawa N, Ren F, Carpenter MA, Ikeda T, Münk C, Harris RS, Miyazawa T, Koyanagi Y, and Sato K. A naturally occurring domestic cat APOBEC3 variant confers resistance to FIV infection. J Virol. 90, 474-85. 2016.
Tennyson RL, Walker SN, Ikeda T, Harris RS, Kennan AJ and McNaughton BR. Helix-grafted Pleckstrin homology domains suppress HIV-1 infection of CD4-positive cells. Chembiochem. 17, 1945-1950. 2016.
2014年
Refsland EW, Hultquist JF, Luengas EM, Ikeda T, Shaban NM, Law EK, Brown WL, Reilly C, Emerman M, and Harris RS. Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity. PLoS Genet. 10, e1004761. 2014.
2013年
Rathore A, Carpenter MA, Demir O, Ikeda T, Li M, Shaban N, Law EK, Anokhin D, Brown WL, Amaro RE, and Harris RS. The local dinucleotide preference of APOBEC3G can be altered from 5’-CC to 5’-TC by a single amino acid substitution. J Mol Biol. 425, 4442-54. 2013.
Maeda K, Almofty SA, Singh SK, Eid MM, Shimoda M, Ikeda T, Koito A, Pham P, Goodman MF, and Sakaguchi N. GANP interacts with APOBEC3G and facilitates its encapsidation into the virions to reduce HIV-1 infectivity. J Immunol. 15, 6030-9. 2013.
2012年
Watanabe N, Ikeda T, Mizuki F, and Tani T. Characterization of the ptr5+ gene involved in nuclear mRNA export in fission Yeast. Biochem Biophys Res Commun. 418, 62-6. 2012.
2011年
Ikeda T, Abd El Galil KH, Tokunaga K, Maeda K, Sata T, Sakaguchi N, Heidmann T, and Koito A. Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons. Nucleic Acids Res. 39, 5538-54. 2011. [論文]
2008年
Ikeda T, Ohsugi T, Kimura T, Matsushita S, Maeda Y, Harada S, and Koito A. The anti-retroviral potency of APOBEC1 deaminase from small animal species. Nucleic Acids Res. 36, 6859-6871. 2008. [論文]
2007年
Ikeda T, Shibata J, Yoshimura K, Koito A, and Matsushita S. Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy. J Infect Dis. 195, 716-25. 2007. [論文]
発表論文: ニュース
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